PUT PATIENTS FIRST
WITH OXLUMO® (lumasiran),
THE FIRST APPROVED THERAPY
FOR THE TREATMENT OF PRIMARY HYPEROXALURIA TYPE 1 (PH1)1-3
OXLUMO is indicated for the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary oxalate (UOx) levels in children and adults. Oxlumo acts at the liver, the site of oxalate production. Overproduction of oxalate is the primary cause of disease manifestation in PH1.1
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Person with PH1

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Treatment with OXLUMO led to powerful reduction in 24-hour urinary oxalate in patients with PH11
Treatment with OXLUMO resulted in a 53% reduction in 24-hour UOx excretion from baseline to month 6 (primary endpoint for ILLUMINATE-A) for OXLUMO compared to placebo in a double-blind clinical trial of 39 patients ≥6 years with eGFR ≥30 mL/min/1.73 m.1,4,5,†
Least squares mean reduction averaged over months 3 through 6, corrected for BSA (OXLUMO, 65%; placebo, 12%); 95% CI: 45%, 62%; P<0.0001 vs placebo.
The dosing regimen for OXLUMO led to a rapid reduction in 24-hr UOx within 2 weeks, which was sustained through 12 months1,4,†
OXLUMO is a subcutaneous injection dosed by weight.
In ILLUMINATE A: 24 hour urinary demonstrated reduction in 24 hr UX excretion from baseline to month 6 for OXLUMO compared to PBO.


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Dedicated support in your patients' journey with Alnylam Assist™
Alnylam Assist™ is committed to providing personalized support throughout treatment with OXLUMO. The program includes patient services in key areas, including understanding insurance benefits and financial assistance options, helping ensure access to therapy, and providing PH1 disease education.
References: 1. OXLUMO (lumasiran) [Package Insert]. Cambridge, MA. Alnylam Pharmaceuticals. 2. Liebow A, Li X, Racie T, et al. J Am Soc Nephrol. 2017;28(2):494-503. 3. Hoppe B. Nat Rev Nephrol. 2012;8(8):467-475. 4. Saland J, Groothoff J, Frishberg Y, et al. Presented at: American Society of Nephrology; October 22-25, 2020. 5. ClinicalTrials.gov identifier: NCT03681184. Updated July 10, 2020. Accessed July 15, 2021. https://clinicaltrials.gov/ct2/show/NCT03681184